Fig. 1.

Genomic structure of human ICAM-1-related (ICR) long non-coding RNA. Positions of annotated human ICR gene transcript (AC011511.5-201, solid line: ENST00000589379.1) and predicted alternative transcript (based on annotated mouse sequence: AC159314.1-201, dashed line: ENSMUST00000216917.1), both located on the anti-sense strand, are indicated in relation to positions of ICAM1 (ENST00000264832.7), ICAM4 (ENST00000380770.3) and ICAM5 (ENST00000221980.4) on chromosome 19p13.2 (genome build = GRCh38.p10; grey indicates coding sequence). Genome evolutionary rate profiling (GERP) identifies evolutionarily constrained elements within a region 500 base pairs upstream of the transcription start sites of the human (A: conserved across 25 eutherians) or mouse (B: conserved across 27 eutherians) ICR gene sequences, plus two polyadenylation signals at the 3′ end of both ICR gene sequences (C: conserved across 26 or 24 eutherians). Phenotype-associated single nucleotide polymorphisms (SNPs) predicted to impact binding of factors that may regulate ICR gene transcription are showed in boxes that correspond to GERP-defined elements