Table 2.

Phenotype-associated single nucleotide polymorphisms (SNPs) and predicted impact of minor allele on binding sites for transcription factors within the human ICAM-1-related (ICR) gene promoter

SNP	Alleles	Minor allele		Transcription factors with binding sites in ICR promoter	Impact of minor allele on binding sites
		Frequency	Associations		Loss	Gain
rs2569693	C/T	0.31	Systemic lupus erythematosus [1] sICAM-1 level [18]	ELF1, POL2, NFKB, MAX, CMYC, E2F6, MXI1, FOXA1, CHD2, HMGN3, ZNF263	PLAGL1, WT1, EGR2, ZKSCAN3, ZBED4, INSM1, MAZR, SALL2, SPZ1	MOK2
rs281439	C/G	0.32	Breast cancer [19]	USF1, USF2, USF3, FOXA1, SIN3AK20, POL2, NFKB, MAX, CMYC, E2F6, MXI1, POL24H8, TCF12, BHLHEAD, HMGN3, IRF1, TBP, YY1, ZNF263	USF	E2F6, GCM1, XCPE
rs281440	A/G	0.30	sICAM-1 level [20]	POL2, TBP, EGR1, SRF, IRF, POL24H8, GATA2, ZNF263	KKLF, ZBTB7, LRRFIP1, E2F4 NM23, MAZR	none
rs2075741	G/C	0.33	Breast cancer [19] Prostate cancer [19] sICAM-1 level [20]	POL2, TAF1, ZNF263	None	DMTE
rs11575074	G/A	0.07	sICAM-1 level [21]	POL2, TAF1, SUZ12, ZNF263	NF1B	MYBL1, MEIS1A_ HOXA9, PTF1

sICAM-1 soluble intercellular adhesion molecule 1