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. 2018 May 9;18:110. doi: 10.1186/s12877-018-0796-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Compared to the adult rats, the protein expression levels of GDNF, GFR-α, and NRG-1 were significantly decreased in the aged group (a), whereas the protein expression levels of α7- and γ-nAChR were increased (b). The protein expression level of α7- and γ-nAChR was significantly increased in the aged rats. GDNF treatment decreased the protein expression of α7- and γ-nAChR but increased that of GFR-α and NRG-1 5 days postinjection (a and b). Values are shown as mean ± SD (n = 10, **P < 0.01)