Table 1. Representative sodium transporters and receptors containing Na+-binding sites.
| PDB entry | Resoln (Å) a | Transporter proteins | Na+-bound ligands b |
| 2A65 26 | 1.65 | Leucine transporter LeuT | Na1: A22bb N27 T254(OG1, O) N286 Leu (substrate) |
| Na2: G20bb V23bb A351bb T354 S355 | |||
| 3KBC 27 | 3.51 | Glutamate transporter GltPh | Na1: G306bb N310bb N401bb D405(OD1; OD2) |
| Na2: T308 S349bb I350bb T352bb | |||
| 4XP1 28 | 2.89 | Dopamine transporter DAT | Na1: A44bb N49 S320bb S320 N352 H2O |
| Na2: G42bb V45bb L417bb D420 S421 | |||
| 5E9S 29 | 2.80 | Glutamate transporter GltTk | Na1: G309bb N313bb N405bb D409(OD1 OD2) |
| Na2: T311bb S352bb I353bb T355bb | |||
| Na3: Y91bb T94 S95 N313 D315 | |||
| 5I71 30 | 3.15 | Serotonin transporter SERT | Na1: A96bb N101 S336bb S336 N368bb |
| Na2: G94bb V97bb L434bb D437 S438 H2O | |||
| 5LM4 31 | 3.10 | Glutamate transporter GLAST1/EAAT1 | T376bb S417bb I418bb A420bb |
| Receptor proteins | |||
| 3C32 23 | 1.72 | Glutamate receptor kainate GluK1 (GluR5) | E96(OE1; O) I99bb D100 H2O |
| 3G3F 32 | 1.38 | Glutamate receptor kainate GluK2 (GluR6) | E97(OE1; O) I100bb D101 H2O |
| 3OM1 33 | 1.68 | Glutamate receptor kainate GluK5 (KA2) | F162bb S165bb E167bb 2(H2O) |
| 3S9E 34 (chain B) | 1.60 | Glutamate receptor kainate GluK3 (GluR7) | Na1: S24bb R26bb 4(H2O) |
| Na2: N5bb S52 2(H2O) | |||
| 3VW7 35 | 2.20 | GPCR receptor protease-activated PAR1 | D148 S189 D367 2(H2O) |
| 4BVN 36 | 2.10 | GPCR receptor adrenergic β1AR | Na1: C192bb D195bb C198bb 2(H2O) |
| Na2: D87 S128 3(H2O) | |||
| 4EIY 37 | 1.80 | GPCR receptor adenosine A2AAR | D52 S91 3(H2O) |
| 4LDE 38 | 2.79 | GPCR receptor adrenergic β2AR | N1103 C1184bb E1187bb C1190bb H2O |
| 4N6H 39 | 1.80 | GPCR receptor opioid δ-OR | D95 N131 S135 2(H2O) |
| 5NDD 40 | 2.80 | GPCR receptor protease-activated PAR2 | D121 D340 N158 S162 N33 |
aResolution of the PDB structure.
bResidues with a superscript “bb” bind to Na+via their backbone carbonyl groups; otherwise, they bind Na+via their sidechain O atoms. Atoms in parenthesis after a residue denotes that both atoms binds to Na+.