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. 2018 Mar 16;10(2):9. doi: 10.1038/s41368-018-0013-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — ERG3 and ERG11 genes are essential for mucosal pathogenesis in vivo. a Images of infected mice tongues with oral candidal leukoplakia after 2-day oropharyngeal infection with wild type (WT), erg3Δ/Δ, and erg11Δ/Δ strain. Leukoplakia on tongue are indicated in vivo by black arrow, while showed by white arrow on incide tissue. b Fungal burdens obtained from the tongues of mice after 2-day oropharyngeal infection with C. albicans WT, erg3Δ/Δ, and erg11Δ/Δ strain. c PAS- and HE-stained tongues from mice 2 days post infection by C. albicans. Including whole-mount and high-magnification views infected by WT strain, erg3Δ/Δ, and erg11Δ/Δ strain. Invading hyphae are indicated by black arrowhead and inflammatory cells are showed by blue arrowhead. d Average percentage of the mice entire tongue epithelium area infected by WT, erg3Δ/Δ, and erg11Δ/Δ strain. e Susceptibility of C. albicans to macrophagocyte have no difference when co-cultured with WT, erg3Δ/Δ strain, and erg11Δ/Δ strain. PAS Periodic Acid-Schiff, HE hematein eosin