Table 4.
Effect of the oral pretreatment with ethanolic extract of the leaves of Spondias mombin (SmEE) on gastric lesions induced by absolute ethanol in rats.
| Pretreatment | Absolute ethanol-induced ulcer | ||
|---|---|---|---|
| Lesion area (mm2) | LPO (nmol of MDA/mg protein) | −SH groups (nmol/mg protein) | |
| Injured control (LC) | 229.80 ± 11.00 | 0.29 ± 0.02 | 1.80 ± 0.32 |
| Lansoprazole (30 mg/kg) | 24.67 ± 3.50∗∗∗ | 0.13 ± 0.02∗∗∗ | 4.72 ± 0.56∗∗ |
| SmEE (50 mg/kg) | 175.00 ± 17.78∗∗ | 0.18 ± 0.00∗∗∗ | 4.66 ± 0.42∗ |
| SmEE (100 mg/kg) | 22.20 ± 3.22∗∗∗ | 0.18 ± 0.01∗∗∗ | 4.75 ± 0.85∗∗ |
| SmEE (200 mg/kg) | 22.35 ± 2.14∗∗∗ | 0.21 ± 0.01∗∗ | 4.49 ± 0.36∗ |
LPO: lipid peroxidation; −SH groups: nonprotein sulfhydryl groups. The results are expressed as the mean ± SEM (n = 5–7/group). ANOVA followed Dunnett's multiple comparisons test; ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001.