Fig. 4. Cellular uptake (A) and DNA platination (B). (A) PSN-1 cells were incubated for 24 h with 1 μM of tested complexes. (B) Platination levels of nuclear DNA extracts. PSN-1 cells were treated for 24 h with 1 μM of tested complexes. DNA was extracted, quantified and the amount of Pt bound to DNA was estimated by GF–AAS. The IC50 values of the compounds against the PSN-1 cells are depicted in red.
