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. 2018 Apr 24;9(18):4299–4307. doi: 10.1039/c8sc00428e

Scheme 1. The Pt(iv) prodrugs were prepared from cisplatin that was oxidized to oxoplatin with H2O2. Two successive carboxylations of oxoplatin with the different anhydrides yield “triple action” prodrugs that are reduced in the cell releasing cisplatin as well as the two bioactive axial ligands.

Scheme 1