Table 1. Cytotoxicity assessed by the MTT test. Cells (3–8 × 10⁴ mL^–1) were treated for 72 h with increasing concentrations of tested compounds. IC₅₀ values were calculated by a four parameter logistic model (P < 0.05). Resistant factor (RF) is defined as IC₅₀ resistant/parent line.

Class	Cmpd	IC50 (μM)
		HCT-15 colon	BCPAP thyroid	PSN-1 pancreas	LoVo colon	2008 ovary	C13* ovary	RF	Average
COXi, PDKi	CAD	1.03 ± 0.25	0.06 ± 0.005	0.06 ± 0.008	0.755 ± 0.06	0.61 ± 0.19	1.66 ± 0.09	2.7	0.70
	CID	0.65 ± 0.17	0.14 ± 0.04	0.08 ± 0.01	0.285 ± 0.02	0.32 ± 0.09	0.97 ± 0.22	3.0	0.41
HDACi, COXi	CPA	1.86 ± 0.41	0.06 ± 0.004	0.09 ± 0.02	0.055 ± 0.01	0.29 ± 0.11	0.43 ± 0.12	1.5	0.46
	CPI	4.98 ± 1.25	0.08 ± 0.01	0.92 ± 0.2	0.211 ± 0.08	0.89 ± 0.19	1.65 ± 0.11	1.9	1.46
	CVA	4.51 ± 0.85	0.01 ± 0.003	0.13 ± 0.04	0.97 ± 0.08	0.69 ± 0.08	0.77 ± 0.04	1.1	1.18
	CVI	3.98 ± 0.89	0.68 ± 0.08	0.07 ± 0.01	0.034 ± 0.03	1.35 ± 0.29	1.61 ± 0.42	1.2	1.29
HDACi, PDKi	CPD	1.06 ± 0.13	0.11 ± 0.03	0.10 ± 0.02	0.019 ± 0.01	0.33 ± 0.04	0.58 ± 0.06	1.8	0.37
	CVD	3.11 ± 1.02	0.01 ± 0.004	0.61 ± 0.1	0.757 ± 0.23	1.12 ± 0.20	1.39 ± 0.37	1.2	1.17
Average IC 50		2.65	0.14	0.26	0.39	1.13	0.71
Ref.	CDDP	15.28 ± 2.63	7.38 ± 1.53	18.25 ± 3.11	9.15 ± 2.07	2.22 ± 1.02	22.52 ± 3.15	10.1	12.47
	OXP	1.15 ± 0.43	4.37 ± 1.07	8.25 ± 3.42	1.01 ± 0.34	1.53 ± 0.88	3.06 ± 1.00	2.0	3.23