Table 2.

Odds ratios of cognitive impairment by baseline galectin-3

Model	Quartile of galectin-3				P for trend∗
	1	2	3	4
	0.1–7.8 ng/mL	7.8–9.9 ng/mL	9.9–12.8 ng/mL	>12.8 ng/mL
Model 0	1 (Ref)	1.00 (0.68–1.46)	1.45 (1.01–2.10)	1.58 (1.10–2.27)	.003
Model 1	1 (Ref)	1.02 (0.69–1.51)	1.49 (1.02–2.17)	1.62 (1.10–2.39)	.004
Model 2	1 (Ref)	0.97 (0.60–1.57)	1.52 (0.94–2.46)	1.27 (0.76–2.12)	.15
Model 3	1 (Ref)	0.98 (0.60–1.59)	1.57 (0.97–2.56)	1.25 (0.75–2.10)	.16

Abbreviations: LDL, low density lipoprotein; Ref, reference group.

NOTE. Model 0: unadjusted.

NOTE. Model 1: adjusted for age, sex, and race.

NOTE. Model 2: adjusted for above + region, education, income, alcohol use, smoking status, physical activity, hypertension medication use, LDL cholesterol, diabetes, systolic blood pressure, left ventricular hypertrophy, history of heart disease, atrial fibrillation, congestive heart failure, and estimated glomerular filtration rate.

NOTE. Model 3: adjusted for above + apolipoprotein e4 allele present.

^∗Trend across quartiles as an ordinal variable 1, 2, 3, and 4.