Figure 5.

Microphotograph sections of the liver of control rats (A and B) and rats subjected to 50 injections of 10-nm SDNPs (C–H), stained by H&E.

Notes: (A) In control rats, the hepatic architecture demonstrates intact hepatic strands radiating outward from a central vein. (B) In control rats, hepatocytes display eosinophilic cytoplasm separated by vascular channels. The round nuclei dispersing smooth chromatin are shown. (C) Hydropic degeneration demonstrating swelling and cytoplasmic vacuolization. (D) Karyopyknosis showing nuclei shrinkage and chromatin condensation. (E) Infiltration of inflammatory cells demonstrating aggregation of inflammatory cells in the hepatic portal space. (F) Infiltration of lobular inflammatory cells (mainly lymphocytes) in the lobular hepatic strands. (G) Hyperplasia of Kupffer cells showing enlargement and hypertrophy of these defense cells. (H) Sinusoidal dilatation exhibiting widening of the capillaries lining the hepatic strands.

Abbreviations: H&E, with hematoxylin and eosin; SDNPs, silicon dioxide nanoparticles.