Table 5.
Hematological analysis of control rats and those received 20, 35 or 50 injections of SDNPs (2 mg/kg bw)
| Test | Unit | Control | 2 mg/20 injections | 2 mg/35 injections | 2 mg/50 injections |
|---|---|---|---|---|---|
| WBCs | 103/μL | 6.68±0.8 | 5.54±0.7 | 8.56±0.9 | 9.89±1* |
| RBCs | 106/μL | 7.55±1 | 8.23±0.8 | 8.45±0.9 | 7.25±1 |
| Hb | g/dL | 15.3±2 | 14.6±2 | 13.4±2 | 13.2±2 |
| HCT | % | 45.7±3.2 | 47.4±4.1 | 49.7±3.8 | 46.2±3.1 |
| MCV | fL (μm3) | 57.8±3.0 | 60.0±4.2 | 58.5±4.2 | 56.3±3.2 |
| MCH | pg | 17.5±2 | 17.7±2 | 16.8±2 | 16.2±1.6 |
| MCHC | g/dL | 29.1±3 | 29.6±3.2 | 30.8±2.7 | 29.7±3.2 |
| Platelets | 103/μL | 814±93 | 887±83 | 995±107 | 986±110* |
| RDW-SD | % | 40.3±3.6 | 41.8±4.2 | 41.3±5 | 43.6±5.7 |
| RDW-CV | % | 19.7±2.2 | 21.1±2.5 | 21.6±3 | 23.5±3.2 |
| PDW | % | 10.6±1 | 9.9±1.2 | 10.2±1.3 | 8.1±1 |
| MPV | fL (μm3) | 9.8±1.1 | 8.2±1.2 | 9.3±1.3 | 7.4±1.1 |
| P-LCR | % | 21.42±3.41 | 16.2±4.11 | 15.7±2.84 | 7.5±5.25* |
| PCT | % | 0.79±0.01 | 0.71±0.01 | 0.66±0.01 | 0.66±0.02* |
Note:
A significant difference (p-value of <0.05) in comparison with the control using ANOVA test.
Abbreviations: ANOVA, analysis of variance; Hb, hemoglobin; HCT, hematocrit; MCH, mean corpuscular hemoglobin; MCHC, mean RBCs hemoglobin concentration; MCV, mean corpuscular volume; NPs, nanoparticles; RBCs, red blood cells; RDW-CV, relative distribution width of RBC by volume-coefficient of variation; RDW-SD, relative distribution width of RBC by volume-standard deviation; PCT, plateletcrit; PDW, platelet volume distribution width; P-LCR, platelet larger cell ratio; WBCs, white blood cells; bw, body weight; MPV, mean platelet volume; SDNPs, silicon dioxide nanoparticles.