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. 2018 Mar 22;2(5):607–620. doi: 10.1002/hep4.1159

Figure 5.

Figure 5

Effect of exercise in sorafenib‐treated rats. Effect of exercise+sorafenib versus sedentary+sorafenib on (A) total tumor volume, (B) necrosis and viable tumor volume, (C) cell proliferation, (D) microvessel density. (E) Immunoblots for protein expression and phosphorylation status in tumor tissue. (F) Immunoblots were quantified and normalized with vinculin. Protein quantification was calculated from six samples per group [mean ± SD]. Western blot images shown are representative images as each experiment was repeated a minimum of 3 times. *P < 0.05; **P < 0.01. Abbreviations: 4E‐BP1, 4E‐binding protein 1; LKB1, liver kinase B1; p‐4E‐BP1, phosphorylated 4E‐BP1; p‐ACC, phosphorylated ACC; p‐Akt, phosphorylated Akt; p‐AMPK, phosphorylated AMPK; p‐S6‐RP, phospho‐S6‐RP; p‐STAT3, phosphorylated STAT3.