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IL‐17A secretion induced neutrophil‐dependent hepatotoxicity in THIF‐1KO mice. (A) Serum IL‐17A levels in APAP‐treated mice (n = 11‐17). (B) Serum ALT levels and (C) number of hepatic neutrophils (CD45+CD11b+Ly6G+) of mice treated with either control IgG or anti‐IL‐17A antibody in AILI (n = 4‐6). *P < 0.05. Data represent mean ± SEM. Abbreviation: IgG, immunoglobulin G. One IU (international unit) / L = 1 Karmen × 0.482.
