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Signaling lymphocytic activation molecule F7 (SLAMF7) structure and signaling mechanism. SLAMF7 is a self‐ligand that recognizes and binds to SLAMF7 on other cells (e.g., myeloma cells can bind to other myeloma cells via SLAMF7 coupling). Natural killer (NK) cell activation after SLAMF7 coupling is dependent on Ewing's sarcoma‐associated transcript 2 (EAT‐2) signaling. Ig, immunoglobulin; ITSM, immunoreceptor tyrosine‐based switch motif; SH2, Src homology 2.
