Table 2.

Summary of clinically relevant models for data generation

Model	Description	Relationship for covariates in hazard function
A	Interaction between ECOG and Ctrough	${\beta }_1\times ECOG+{\beta }_2\times Tumorsize+{\beta }_3\times C_{trough}+{\beta }_{13}\times ECOG\times C_{trough}$
B	Nonlinear drug exposure effects	${\beta }_1\times ECOG+{\beta }_2\times Tumorsize+{\beta }_{13}\times \frac{60\times C_{trough}}{30+C_{trough}}$
C	Interaction between nonlinear drug exposure effect and ECOG	${\beta }_1\times ECOG+{\beta }_2\times Tumorsize+{\beta }_{13}\times \frac{60\times C_{trough}}{30+C_{trough}}\times (1-ECOG)$