Table 2.

Clinical trials that support the role of statins in AMD

Trial	Design	Follow-up	Drug	Results
Vavvas et al. [14]	Open-label prospective 26 subjects	1 year	80 mg atorvastatin daily	Regression of drusenoid RPE detachment in 10 patients and vision gain of 3.3 letters. None developed advanced AMD (Geographic atrophy or CNV).
Barbosa et al. [37]	Cross-sectional 5604 subject	2005-2008	Statins	Possible beneficial effect of statins use for AMD prevention in subject’s ≥ 68 years of age. The benefit was greater with the longer use of statins.
Guymer et al. [39]	Randomised controlled trial 114 subjects	3 years	40 mg simvastatin/placebo	Four-fold decrease in AMD progression in simvastatin group compared to placebo and greater benefit was observed in CFH gene carriers.
The Blue Mountains Eye Study [33]	Population-based cohort study, 3654 at baseline	5 and 10 years	Statins	Statins users had reduced risk of development of indistinct soft drusen, but there was no significant association between statins and the incidence of early AMD.