Table 6.
Comparison of improvement in health-related quality of life patients between genotypes
| SNP | Dominant model | Recessive model | ||||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| Wild | Heterozygous/homozygous mutant | P-value | PBH | Wild/heterozygous | Homozygous mutants | P-value | PBH | |
| rs3794241 | 181 (62.20) | 110 (37.80) | 276 (94.85) | 15 (5.15) | ||||
| Total score | 5.00 (-0.94-11.29) | 7.97 (0.81-17.94) | 0.075 | 0.275 | 5.69 (0.06-13.61) | 13.81 (1.88-24.50) | 0.232 | 0.843 |
| Physical function | 5.00 (0-25.00) | 10.00 (0-25.00) | 0.426 | 0.484 | 7.50 (0-25.00) | 10.00 (0-20.00) | 0.604 | 0.845 |
| Role-physical | 0 (0-0) | 0 (0-50.00) | 0.133 | 0.366 | 0 (0-0) | 0 (0-100.00) | 0.052 | 0.572 |
| Bodily pain | 11.00 (0-26.00) | 10.00 (0-23.00) | 0.440 | 0.484 | 10.00 (0-26.00) | 10.00 (0-29.00) | 0.890 | 0.890 |
| General health | 0 (0-5.00) | 5.00 (0-10.00) | 0.209 | 0.396 | 5.00 (0-5.00) | 5.00 (-10.00-20.00) | 0.691 | 0.845 |
| Vitality | 0 (-5.00-10.00) | 0 (0-10.00) | 0.359 | 0.484 | 0 (-5.00-10.00) | 0 (-10.00-15.00) | 0.674 | 0.845 |
| Social function | 0 (0-12.50) | 0 (0-12.50) | 0.440 | 0.484 | 0 (0-12.50) | 0 (-12.50-12.50) | 0.401 | 0.843 |
| Role-emotional | 0 (0-0.00) | 0 (0-33.33) | 0.029 | 0.226 | 0 (0-0) | 0 (0-100.00) | 0.396 | 0.843 |
| Mental health | 0 (-4.00-4.00) | 0 (-4.00-4.00) | 0.883 | 0.883 | 0 (-4.00-4.00) | -4.00 (-8.00-4.00) | 0.460 | 0.843 |
| Physical componen summary | 6.75 (0.50-16.25) | 11.88 (0.25-19.75) | 0.216 | 0.396 | 7.75 (0.38-17.75) | 18.00 (3.75-35.75) | 0.143 | 0.787 |
| Mental component summary | 2.13 (-1.63-8.75) | 4.75 (-0.50-16.20) | 0.041 | 0.226 | 2.79 (-1.06-10.67) | 2.13 (-4.13-24.00) | 0.786 | 0.865 |
| rs1165681 | 94 (32.30) | 197 (67.70) | 233 (80.07) | 58 (19.93) | ||||
| Total score | 6.13 (0.81-14.50) | 5.63 (-1.88-14.13) | 0.710 | 0.979 | 5.79 (0-14.19) | 6.53 (0.75-17.13) | 0.762 | 0.946 |
| Physical function | 10.00 (0-25.00) | 5.00 (0-25.00) | 0.239 | 0.979 | 5.00 (0-25.00) | 10.00 (0-25.00) | 0.947 | 0.947 |
| Role-physical | 0 (0-25.00) | 0 (0-0) | 0.495 | 0.979 | 0 (0-25.00) | 0 (0-0) | 0.897 | 0.947 |
| Bodily pain | 10.00 (0-26.00) | 11.00 (0-23.00) | 0.979 | 0.979 | 12.00 (0-26.00) | 0 (0-22.00) | 0.035 | 0.193 |
| General health | 0 (0-5.00) | 5.00 (0-10.00) | 0.397 | 0.979 | 5.00 (0-5.00) | 2.50 (-5.00-10.00) | 0.683 | 0.946 |
| Vitality | 0 (-5.00-10.00) | 0 (0-10.00) | 0.764 | 0.979 | 0 (-5.00-10.00) | 5.00 (0.00-10.00) | 0.091 | 0.334 |
| Social function | 6.25 (0-12.50) | 0 (0-12.50) | 0.055 | 0.605 | 0 (0-12.50) | 0 (0-12.50) | 0.018 | 0.193 |
| Role-emotional | 0 (0-33.33) | 0 (0-0) | 0.930 | 0.979 | 0 (0-0) | 0 (0-33.33) | 0.230 | 0.618 |
| Mental health | 0 (-4.00-4.00) | 0 (-4.00-4.00) | 0.938 | 0.979 | 0 (-4.00-4.00) | 0 (-4.00-4.00) | 0.774 | 0.946 |
| Physical component summary | 8.38 (1.25-19.50) | 7.75 (0.25-18.75) | 0.721 | 0.979 | 8.00 (0.50-19.50) | 7.63 (1.25-17.00) | 0.592 | 0.946 |
| Mental component summary | 3.50 (-1.00-10.87) | 2.13 (-1.25-10.88) | 0.572 | 0.979 | 2.25 (-1.25-10.58) | 4.98 (-1.00-13.75) | 0.281 | 0.618 |
| rs2722188 | 201 (69.07) | 90 (30.93) | 287 (98.63) | 4 (1.37) | ||||
| Total score | 6.06 (0.75-14.66) | 5.56 (-1.13-11.06) | 0.226 | 0.413 | 6.06 (0.13-14.50) | -1.41 (-10.13-0.63) | 0.029 | 0.106 |
| Physical function | 10 (0-25) | 5.00 (0-25.00) | 0.335 | 0.461 | 10.00 (0-25.00) | 0 (-15.00-5.00) | 0.099 | 0.143 |
| Role-physical | 0 (0-25.00) | 0 (0-0) | 0.079 | 0.300 | 0 (0-25.00) | 0 (0-0) | 0.461 | 0.521 |
| Bodily pain | 11.00 (0-26.00) | 10.00 (0-23.00) | 0.414 | 1.000 | 11.00 (0-26.00) | -3.00 (-16.00-0) | 0.027 | 0.106 |
| General health | 5.00 (0-10.00) | 0 (-5.00-5.00) | 0.191 | 0.413 | 5.00 (0-10.00) | -5.00 (10.00-0) | 0.104 | 0.143 |
| Vitality | 0 (-5.00-10.00) | 5.00 (0-10.00) | 0.075 | 0.300 | 0 (-5.00-10.00) | -5.00 (-17.50-0) | 0.057 | 0.136 |
| Social function | 0 (0-12.50) | 0 (0-12.50) | 0.263 | 0.413 | 0 (0-12.50) | -6.25 (-12.50-0) | 0.074 | 0.136 |
| Role-emotional | 0 (0-33.33) | 0 (0-0) | 0.109 | 0.300 | 0 (0-0) | 0 (0-0) | 0.474 | 0.521 |
| Mental health | 0 (-4.00-4.00) | 0 (-4.00-8.00) | 0.776 | 0.854 | 0 (-4.00-4.00) | 0 (-18.00-8.00) | 0.724 | 0.724 |
| Physical component summary | 8.00 (1.25-19.50) | 7.88 (-0.25-14.00) | 0.104 | 0.300 | 8.75 (1.25-19.25) | -0.75 (-9.50-0.50) | 0.025 | 0.106 |
| Mental component summary | 2.88 (-1.25-10.88) | 2.31 (-1.00-10.25) | 0.667 | 0.815 | 2.88 (-1.13-10.88) | -2.81 (-10.75-0.75) | 0.074 | 0.136 |
| rs3794240 | 146 (50.17) | 145 (49.83) | 275 (94.50) | 16 (5.50) | ||||
| Total score | 4.16 (-1.13-10.56) | 7.94 (1.75-17.13) | 0.027 | 0.132 | 5.81 (0.13-14.19) | 4.69 (0.63-14.58) | 0.862 | 0.882 |
| Physical function | 5.00 (0-25.00) | 10.00 (0-25.00) | 0.271 | 0.336 | 10.00 (0-25.00) | 5.00 (0-15.00) | 0.523 | 0.882 |
| Role-physical | 0 (0-0) | 0 (0-50.00) | 0.058 | 0.132 | 0 (0-25.00) | 0 (0-37.50) | 0.354 | 0.882 |
| Bodily pain | 10.00 (0-23.00) | 11.00 (0-26.00) | 0.399 | 0.439 | 10.00 (0-26.00) | 5.00 (0-18.50) | 0.367 | 0.882 |
| General health | 0 (-5.00-5.00) | 5.00 (0-10.00) | 0.141 | 0.253 | 5.00 (0-10.00) | 2.50 (0-7.50) | 0.878 | 0.882 |
| Vitality | 0 (-5.00-10.00) | 0 (0-10.00) | 0.275 | 0.336 | 0 (-5.00-10.00) | 0 (-5.00-0) | 0.047 | 0.517 |
| Social function | 0 (0-12.50) | 0 (0-12.50) | 0.161 | 0.253 | 0 (0-12.50) | 0 (0-12.50) | 0.882 | 0.882 |
| Role-emotional | 0 (0-0) | 0 (0-33.33) | 0.059 | 0.132 | 0 (0-0) | 0 (0-33.33) | 0.149 | 0.820 |
| Mental health | 0 (-4.00-4.00) | 0 (-4.00-4.00) | 0.679 | 0.679 | 0 (-4.00-4.00) | 0 (-4.00-4.00) | 0.753 | 0.882 |
| Physical component summary | 6.25 (0-15.00) | 10.25 (1.25-21.75) | 0.06 | 0.132 | 8.25 (0-19.25) | 6.00 (0.13-18.88) | 0.873 | 0.882 |
| Mental component summary | 1.69 (-2.25-9.58) | 3.50 (-0.50-11.21) | 0.042 | 0.132 | 2.50 (-1.25-2.50) | 3.98 (-.63-10.79) | 0.566 | 0.882 |
| rs10861147 | 202 (69.42) | 89 (30.58) | 286 (98.28) | 5 (1.72) | ||||
| Total score | 5.97 (0.75-14.50) | 5.63 (-1.13-14.13) | 0.287 | 0.526 | 5.97 (0.13-14.38) | 0.38 (-3.19-0.88) | 0.130 | 0.464 |
| Physical function | 5.00 (0-25.00) | 10.00 (0-25.00) | 0.886 | 0.886 | 10.00 (0-25.00) | 0 (0-10.00) | 0.238 | 0.464 |
| Role-physical | 0 (0-25.00) | 0 (0-0) | 0.150 | 0.526 | 0 (0-25.00) | 0 (0-0) | 0.409 | 0.464 |
| Bodily pain | 10.00 (0-26.00) | 11.00 (0-26.00) | 0.765 | 0.842 | 11.00 (0-26.00) | 0 (-6.00-0) | 0.02 | 0.22 |
| General health | 5.00 (0-10.00) | 5.00 (-5.00-5.00) | 0.528 | 0.645 | 5.00 (0-10.00) | -5.00 (-5.00-5.00) | 0.351 | 0.464 |
| Vitality | 0 (-5.00-10.00) | 5.00 (0-10.00) | 0.259 | 0.526 | 0 (-5.00-10.00) | 0 (-10.00-0) | 0.360 | 0.464 |
| Social function | 0 (0-12.50) | 0 (0-12.5) | 0.058 | 0.526 | 0 (0-12.50) | 0 (-12.50-0) | 0.210 | 0.464 |
| Role-emotional | 0 (0-0) | 0 (0-0) | 0.199 | 0.526 | 0 (0-0) | 0 (0-0) | 0.422 | 0.464 |
| Mental health | 0 (-4.00-4.00) | 0(-4.00-8.00) | 0.497 | 0.645 | 0 (-4.00-4.00) | 8.00 (-8.00-8.00) | 0.658 | 0.658 |
| Physical component summary | 7.88 (1.25-19.25) | 8.75 (-0.25-17.00) | 0.273 | 0.526 | 8.50 (1.25-19.25) | -0.25 (-1.25-1.25) | 0.048 | 0.264 |
| Mental component summary | 3.13 (-1.00-10.88) | 2.00 (-2.50-10.25) | 0.359 | 0.564 | 2.88 (-1.13-10.88) | -0.50 (-5.13-2.00) | 0.313 | 0.464 |