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Effect of LPS on plasma and brain levels of IL-6. A. Plasma levels of IL-6 transiently peaked at 5 times control levels at 2-4 h post LPS and thereafter dropped to control levels by 24 h. B. The magnitude of increase in IL-6 in the brains of LPS animals was 2 times greater than control levels, peaking at 24 h but continuing through 7-9 d post LPS. Statistically significant differences noted: (*).
