Table 1.
Cytokine levels, as determined by ELISA, in the brain and plasma of control rats and those at intervals following a single intraperitoneal injection of 10 mg/kg LPS
| IL-1β | |||||
|
| |||||
| Interval from LPS injection | N | Brain mean pg/mg (SE) | Brain p = LPS vs. control | Plasma mean pg/ml (SE) | Plasma p = LPS vs. control |
|
| |||||
| Control | 13 | 11.43 (0.85) | 621.10 (117.74) | ||
| 2 h | 5 | 14.19 (0.76) | < 0.02 | 651.87 (175.68) | NS |
| 4 h | 5 | 17.97 (0.72) | < 0.01 | 1283.74 (109.07) | < 0.05 |
| 24 h | 8 | 89.90 (10.79) | < 0.0001 | 1245 (211.90) | < 0.05 |
| 3 d | 8 | 23.36 (3.79) | < 0.01 | 1058.42 (96.61) | < 0.05 |
| 7-9 d | 8 | 22.84 (2.51) | < 0.001 | 1142.00 (182.69) | < 0.05 |
|
| |||||
| IL-6 | |||||
|
| |||||
| Interval from LPS injection | N | Brain mean pg/mg (SE) | Brain p = LPS vs. control | Plasma mean pg/ml (SE) | Plasma p = LPS vs. control |
|
| |||||
| Control | 13 | 11.41 (1.06) | 780.05 (119.69) | ||
| 2 h | 5 | 8.79 (0.93) | NS | 3805.66 (531.03) | < 0.0001 |
| 4 h | 5 | 9.40 (0.29) | NS | 3903.92 (507.27) | < 0.0001 |
| 24 h | 8 | 22.47 (0.79) | < 0.0001 | 652.83 (17.24) | NS |
| 3 d | 8 | 16.01 (1.05) | < 0.01 | 634.12 (26.67) | NS |
| 7-9 d | 8 | 18.67 (1.09) | < 0.001 | 655.27 (17.31) | NS |
|
| |||||
| TNFα | |||||
|
| |||||
| Interval from LPS injection | N | Brain mean pg/mg (SE) | Brain p = LPS vs. control | Plasma mean pg/ml (SE) | Plasma p = LPS vs. control |
|
| |||||
| Control | 13 | 13.19 (0.86) | 224.63 (16.70) | ||
| 2 h | 5 | 12.18 (0.82) | NS | 168.67 (20.59) | NS |
| 4 h | 5 | 12.65 (0.66) | NS | 571.91 (97.28) | < 0.0001 |
| 24 h | 8 | 18.87 (1.81) | < 0.01 | 281.14 (31.97) | NS |
| 3 d | 8 | 14.61 (1.86) | NS | 235.57 (17.04) | NS |
| 7-9 d | 8 | 13.52 (1.60) | NS | 218.67 (19.43) | NS |
SE = standard error of the mean.