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. 2017 Oct 16;125(10):107006. doi: 10.1289/EHP1937

Figure 4.

Figures 4A and 4B are graphical representations, respectively, plotting average chromatin accessibility log sub 2 (NC plus 1) and average expression log sub 2 (NC plus 1) (y-axis) in C57BL/6J control mice, C57BL/6J BD-exposed mice, CAST/EiJ control mice, and CAST/EiJ BD-exposed mice (x-axis). Figure 4C shows sequence reads of representative loci Irf7 in CAST/EiJ BD-exposed mice, CAST/EiJ control mice, C57BL/6J BD-exposed mice, and C57BL/6J control mice.

Accessibility of Sp1 motif-containing differentially accessible regions (DARs) and expression of associated genes according to 1,3-butadiene (BD) exposure and strain. (A) Differences in chromatin accessibility in proximal regions containing the Sp1 motif in the lung of control and 1,3-butadiene-exposed mice of both strains (independent t-test, *p<0.05, **p<0.001) (B) Differences in messenger RNA (mRNA) level of genes associated with these regions in the same tissues (independent t-test, *p<0.05, **p<0.001). (C) Difference in mRNA level of the immune response pathway gene Irf7, the locus for which contains an Sp1 motif, following 1,3-butadiene exposure in C57BL/6J and CAST/EiJ mice.