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. 2017 Oct 16;125(10):107006. doi: 10.1289/EHP1937

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EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.

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Figures 6A and 6B are schematic diagrams. — Conceptual model of strain-specific differences in gene expression and chromatin state in the lung in response to 1,3-butadiene (BD) exposure. (A) Gene expression and chromatin accessibility of detoxification pathways, as well as those related to energy metabolism and the DNA damage response, in the lung of unexposed CAST/EiJ relative to the lung of unexposed C57BL/6J. (B) Changes in C57BL/6J detoxification-related gene expression and regulation profiles after exposure to 1,3-butadiene result in a molecular state that resembles that of CAST/EiJ. miRNA, microRNA.