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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: J Neuroimmune Pharmacol. 2016 Dec 22;12(2):314–326. doi: 10.1007/s11481-016-9719-0

Figure 9.

Figure 9

gp120 potentiation of glutamate-induced increase of [Ca2+]I via NMDARs. A. An example of Ca2+ imaging study showing gp120 potentiation of glutamate (Glu)-induced Ca2+ influx via NMDARs in a cultured rat hippocampal neuron. Note that gp120 produced an increase of [Ca2+ ]I in the presence of an AMPAR antagonist CNQX (10μM). The gp120-associated potentiation disappeared when NMDARs were blocked by addition of a specific NMDAR antagonist APV, demonstrating that gp120 interacts with NMDARs. B. Bar graph shows average [Ca2+ ]I in different experimental conditions and illustrates gp120 potentiation of Glu-induced increase of [Ca2+ ]I via NMDARs. Experiments were done in triplicates. n=12, * p < 0.05 vs control.