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Solid lines show relative bacterial killing rate constants (kkill/Emax) as a function of concentration for INH susceptible Mtb (A-C) and RIF susceptible Mtb (D-F). Dotted lines show curves for INH- and RIF-resistant Mtb. Gray bars show the range of concentrations that intracellular (A,D), extracellular (B,E) or non-replicating (C,F) Mtb are exposed to over the first 7 days of treatment.
