Table 2. Drug resistance parameter values and ranges used for sensitivity analysis.

Parameter	Value	Sensitivity analysis ranges	References
Mutation frequency [per base pair per day]	3x10-6 (emergence simulations)	3x10-7–1x10-5	[64]
INH
Number of resistance-conferring mutations	30	30–300	[91–93]
Relative fitness [fraction of WT growth rate]	0.9	0–1	[25]
Number of compensatory mutations	1	1–10	[25, 26, 82, 94]
RIF
Number of resistance-conferring mutations	30	30–300	[91, 95]
Relative fitness [fraction of WT growth rate]	0.8	0–1	[73, 74]
Number of compensatory mutations	40	40–400	[22, 80, 94, 95]