Fig 3. Chromosomal and genomic analyses of NKX3-2.
(A) SKY analysis of CCRF-CEM revealed the aberration t(8;9). The loci for NKX3-2, NKX2-5 and SIX6 are indicated. (B) FISH analysis of the NKX3-2 locus in CCRF-CEM demonstrates wild type configurations (N4: normal chromosome 4). Genomic profiling data of T-ALL cell lines CCRF-CEM, JURKAT and PEER for chromosome 4 (C), chromosome 14 (D), chromosome 5 (E), and chromosome 1 (F). The localizations of selected genes including NKX3-2, SIX6, NKX2-5 and TAL1 are indicated.