Table 1. Demographic and clinical characteristics.
| Cases (n = 59) | Controls (n = 189) | p-value | ||
|---|---|---|---|---|
| Age, years, mean (sd) | 49 (±13) | 52 (±13) | 0.23 | |
| Gender, n (%) | Female | 21 (36) | 39 (21) | 0.02 |
| Male | 38 (64) | 150 (79) | ||
| Donor type, n (%) | Deceased donor | 19 (32) | 41 (22) | 0.10 |
| Living donor | 40 (68) | 148 (78) | ||
| Donor age, years, mean (sd) | 51 (±12) | 51 (±13) | 0.71 | |
| Previous Transplantation, n (%) | Yes | 12 (20) | 24 (13) | 0.15 |
| No | 47 (80) | 165 (87) | ||
| Time of Transplantation, year | 2000–2012 | 2000–2012 | ||
| Time to diagnosis, years, median (IQR) | 6.1 (3.5–8.3) | - | ||
| Total HLA mismatch, median (IQR) | 3 (2–5) | 3 (3–5) | 0.70 | |
| PRAa current, mean (range) | 1.5 (0–8) | 3.2 (0–96) | 0.44 | |
| PRA peak, mean (range) | 9.5 (0–62) | 6.6 (0–80) | 0.49 | |
| Previous BPARb, n (%) | Yes | 15 (25) | 36 (19) | 0.30 |
| No | 44 (75) | 153 (81) | ||
| eGFR at t-3, ml/min/1.73m2, mean (sd) | 48 (±12) | 50 (±15) | 0.55 | |
| Trough-level at t-3, ng/mL, mean (sd) | 6.1 (±1.9) | 6.1 (±1.7) | 0.98 | |
| C0 measurements, n, mean (range) | 17 (8–33) | 15 (8–44) | 0.01 | |
| Primary kidney disease, n (%) | Diabetic | 8 (13.6) | 36 (19) | |
| Nephropathy | ||||
| Hypertensive | 10 (16.9) | 44 (23.3) | ||
| Nephropathy | ||||
| IgA Nephropathy | 3 (5.1) | 12 (6.3) | ||
| Polycystic Kidney | 10 (16.9) | 24 (12.7) | ||
| Disease | ||||
| FSGSc | 3 (5.1) | 8 (4.2) | ||
| Obstructive | 1 (1.7) | 7 (3.7) | ||
| Nephropathy | ||||
| Unknown | 3 (5.1) | 11 (5.8) | ||
| Other | 21 (35.6) | 47 (25) |
a PRA, Panel Reactive Antibody;
b BPAR, biopsy proven acute rejection (incl. borderline changes);
c FSGS, Focal Segmental Glomerulosclerosis