Table 2. Concordance of blastocyst ploidy and karyotype per sample and per chromosome assessed by NIPGS vs TE vs WB.
| Analysis of chromosomal aberrations | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Type of samples | Full concordance | Partial concordance | Discordant | Total concordance | |||||
| Blastocyst | Per Chromosome | Blastocyst | Per Chromosome | Blastocyst | Per Chromosome | Blastocyst | Per Chromosome | ||
| (N/%) | (N/%) | (N/%) | (N/%) | (N/%) | (N/%) | (N) | (N/%) | ||
| NIPGS vs. TE biopsy | Embryo ploidy | 21/24 (87.5) | 24 | ||||||
| WCN | 20 (83.3) | 480/480 (100) | 1 (4.2) | 23/24 (95.8) | 3 (12.5) | 69/72 (95.8) | 24 | 572/576 (99.3) | |
| All aberrations* | 16 (66.7) | 384/384 (100) | 5 (20.8) | 110/120 (91.7) | 3 (12.5) | 69/72 (95.8) | 24 | 563/576 (97.8) | |
| NIPGS vs. WB | Embryo ploidy | 27/28 (96.4)a | 28 | ||||||
| WCN | 26 (92.8) | 624/624(100) | 1 (3.6) | 23/24 (95.8) | 1 (3.6) | 23/24 (95.8) | 28 | 670/672 (99.7)b | |
| All aberrations* | 22 (78.5) | 528/528 (100) | 5 (17.9) | 115/120 (95.8) | 1 (3.6) | 23/24 (95.8) | 28 | 666/672 (99.1) | |
| TE biopsy vs. WB | Embryo ploidy | 22/24 (91.7)a | 24 | ||||||
| WCN | 22 (91.7) | 528/528 (100) | 0 | 0 | 2 (8.3) | 46/48 (95.8) | 24 | 574/576 (99.7)b | |
| All aberrations* | 18 (75.0)* | 432/432 (100) | 4 (16.7) | 428/432 (99.1) | 2 (8.3) | 46/48 (95.8) | 24 | 570/576 (98.9) | |
WCN = whole chromosome copy number
*Chromosomal aberrations include: whole chromosome aneuploidy, segmental aneuploidy and/or mosaicism
aMcNemar’s test: The two-tailed P value equals 0.4881.Same superscript in the column indicates the difference are not statistically significant
bFisher exact testing: Same superscript in the column indicates the difference are not statistically significant (P>0.05)