Table 1. Percentage of CYP2C9 channels opened during the MD simulations of the WT and the A477T mutant in the apo, diclofenac- and losartan-bound states.

Simulation system	2a	2b	2c	2ac	2e	2f	4	5	S1	S2
WT apo	17.0	32.1	5.9	0.6	34.9	14.2	0.7	13.8	79.4	31.3
A477T apo	20.4	21.7	6.8	0.1	33.6	9.1	0.3	8.0	67.8	30.1
WT diclofenac	40.7	25.0	10.9	1.9	23.6	17.4	2.3	21.2	67.5	33.1
A477T diclofenac	24.5	23.8	3.7	14.6	20.6	37.7	0.3	15.5	65.8	28.5
WT losartan	6.2	5.9	45.6	0.0	12.6	6.1	1.6	8.0	71.7	12.1
A477T losartan	16.3	21.3	49.7	0.0	5.7	12.5	0.1	10.3	60.5	22.6