Table 1. Baseline characteristics of cirrhotic patient cohort.
| Characteristics | Case group (n = 714) |
Control group (n = 714) |
P value | ||
|---|---|---|---|---|---|
| N | % | N | % | ||
| Age, years (mean ± SD) at LC diagnosis | 55.74±13.35 | 55.74±13.35 | 1.000 | ||
| ≤ 49 | 247 | 34.59% | 247 | 34.59% | 1.000 |
| 50–59 | 194 | 27.17% | 194 | 27.17% | |
| 60–69 | 140 | 19.61% | 140 | 19.61% | |
| ≥70 | 133 | 18.63% | 133 | 18.63% | |
| Gender | |||||
| Male | 548 | 76.75% | 548 | 76.75% | 1.000 |
| Female | 166 | 23.25% | 166 | 23.25% | |
| CCI score (mean ± SD) | 1.39±1.22 | 1.40±1.25 | 0.813 | ||
| Charlson comorbid Index | |||||
| Acute myocardial infarction | 6 | 0.84% | 2 | 0.28% | 0.288 |
| Congestive heart failure | 32 | 4.48% | 39 | 5.46% | 0.394 |
| Peripheral vascular disease | 8 | 1.12% | 14 | 1.96% | 0.197 |
| Cerebral vascular accident | 36 | 5.04% | 51 | 7.14% | 0.097 |
| Dementia | 10 | 1.40% | 10 | 1.40% | 1.000 |
| Pulmonary disease | 75 | 10.50% | 96 | 13.45% | 0.087 |
| Connective tissue disorder | 9 | 1.26% | 6 | 0.84% | 0.436 |
| Liver disease | 458 | 64.15% | 426 | 59.66% | 0.081 |
| Diabetes | 172 | 24.09% | 176 | 24.65% | 0.805 |
| Diabetes complications | 34 | 4.76% | 40 | 5.60% | 0.474 |
| Paraplegia | 3 | 0.42% | 6 | 0.84% | 0.506 |
| Renal disease | 44 | 6.16% | 35 | 4.90% | 0.298 |
| Severe liver disease | 3 | 0.42% | 2 | 0.28% | 1.000 |
| HIV | 2 | 0.28% | 2 | 0.28% | 1.000 |
| Liver-related diagnosis | |||||
| Alcoholism | 161 | 22.55% | 125 | 17.51% | 0.017 |
| Viral hepatitis | 143 | 20.03% | 138 | 19.33% | 0.739 |
| HCC | 0 | 0.00% | 0 | 0.00% | -- |
| Decompensated cirrhosis | 77 | 10.78% | 52 | 7.28% | 0.021 |
| Use of PPI | 32 | 4.48% | 41 | 5.74% | 0.28 |
LC, liver cirrhosis; CCI, Charlson comorbid index; SD, standard deviation; HCC, hepatic cellular carcinoma; PPI = proton pump inhibitors,
Case: patients with HE, control: patient without HE, Patient’s comorbid conditions were identified within 1 year prior to the date of LC diagnosis