Fig 1. Presence and distribution of 152 Mendelian disease alleles in 101,322 dogs.

(A) Frequency distribution of the tested variants highlights a majority of individual disease alleles as absent or rare on a general population level, and a subset of more prevalent disorders. (B) Venn diagram summary of the distribution of disease variants across mixed breed, and purebred dogs. The majority of disorders (N = 80) were observed at least once in both mixed breed and purebred dogs. Other disorders were exclusively observed in either group. Twenty-five of the studied disease variants were not observed in any dog studied. For details on specific disorders and their allele counts, please refer to S3 and S4 Tables.