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. Author manuscript; available in PMC: 2019 Mar 22.
Published in final edited form as: Cell. 2018 Mar 8;173(1):62–73.e9. doi: 10.1016/j.cell.2018.02.026

Figure 6. Loss of STE24 enhanced IAPP oligomer toxicity.

Figure 6

A) Deletion of STE24 produced no growth defect on its own but greatly enhanced 6xIAPP toxicity. This was rescued by reintroducing STE24 on a plasmid under the control of its endogenous promoter. A catalytically inactive E289G Ste24 was much less effective in rescuing the enhanced IAPP toxicity of the Δste24 strain. B) WT human ZMPSTE24 functionally substituted for Ste24 and relieved 6xIAPP toxicity in the Δste24 strain. The effects of substitution with ZMPSTE24 mutants possessing a range of declogging activities are shown in order of decreasing activity (for a measurement of their declogging activity please see (Ast et al., 2016)).