Table 1.

Mean (± SE) morphometrical, biochemical, and hormone measurements in LETO, OLETF, and OLETF + ARB male rats.

	2 wks			11 wks
	LETO (n=5)	OLETF (n=6)	OLETF ARB (n=6)	LETO (n=5)	OLETF (n=6)	OLETF ARB (n=6)
FI (g)	17.7 ± 0.5	25.2 ± 0.7a	24.3 ± 0.9a	19.4 ± 0.5	29.3 ± 1.1a	26.8 ± 0.3a
Retro fat mass (g)1	4.5 ± 0.4	11.4 ± 1.1c	10.8 ± 1.7c	7.7 ± 0.5	23.9 ± 2.0e	16.8 ± 1.8e,f
Epi fat mass (g)1	4.6 ± 0.6	9.7 ± 0.9c	7.1 ± 1.0	7.8 ± 0.7	13.9 ± 1.0e	11.6 ± 1.1
Glucose (mmol/L)	4.1 ± 0.3	6.2 ± 0.1c	6.4 ± 0.4c	4.1 ± 0.3	6.7 ± 0.6e	5.2 ± 0.2f,h
TG (mmol/L)	0.6 ± 0.1	1.1 ± 0.1a	0.8 ± 0.1a,b	0.4 ± 01	1.3 ± 0.2a	0.9 ± 0.1a,b
NEFA (mEq/L)	0.57 ± 0.05	0.89 ± 0.07c	0.79 ± 0.04c	0.63 ± 0.05	0.71 ± 0.04g	0.80 ± 0.10
Adiponectin (ug/mL)	2.43 ± 0.11	2.92 ± 0.32	3.08 ± 0.32	1.90 ± 0.10§	2.50 ± 0.18§	2.07 ± 0.13§
IRI (r.u. x 106)	4.2 ± 1.9	4.9 ± 1.4	9.1 ± 3.3	3.5 ± 8.6	16.5 ± 4.8e,g	4.2 ± 1.6f

Comparisons were assessed using a two factor ANOVA with group and time as between-subject factors or ¹a one-way ANOVA at each time point.

FI, food intake; BM, body mass; TG, triglycerides; NEFA, non-esterified fatty acids; IRI, insulin resistance index.

Main effects:

^ap < 0.05 vs. LETO;

^bp < 0.05 vs. OLETF;

^§p < 0.05 vs. 2 wks.

Pairwise comparisons:

^cp < 0.05 vs. LETO 2 wks;

^ep < 0.05 vs. LETO 11 wks;

^fp < 0.05 vs. OLETF 11 wks;

^gp < 0.05, OLETF 2 wks vs. OLETF 11 wks;

^hp <0.05, OLETF ARB 2 wks vs. OLETF ARB 11 wks.