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. Author manuscript; available in PMC: 2018 May 10.
Published in final edited form as: Biochemistry. 2016 Aug 17;55(34):4787–4797. doi: 10.1021/acs.biochem.6b00430

Table 3.

Thermodynamic Parameters of the Interactions of CRAC336WT with Sterolsa

KD (M) ΔH (kJ/mol) ΔS (kJ mol−1 K−1) −TΔS (kJ/mol) ΔG (kJ/mol)
CRAC336WT and POPC 3.81 × 10−3 32.58 0.155 −46.8 −14.2
CRAC336WT and Chol 5.05 × 10−8 2.81 0.152 −46.2 −43.4
CRAC336WT and Desmo 2.39 × 10−4 1.508 0.074 −22.42 −20.9
CRAC336WT and DHC 2.53 × 10−7 2.66 0.135 −40.91 −38.3
CRAC336WT and CC 6.86 × 10−2 −0.80 0.019 −5.76 −4.96
a

The affinity and thermodynamic properties were obtained using the independent or two-site model, as described in Materials and Methods.