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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Hypertension. 2018 Apr 30;71(6):1156–1163. doi: 10.1161/HYPERTENSIONAHA.118.10934

Figure 2. ICV minocycline treatment reduces the RV fibrosis (RVF) and hypertrophy (RVH) induced by MCT.

Figure 2

A, Representative micrographs of collagen stained with Picro Sirius Red revealing increased fibrosis in MCT-treated rats. B, Cumulative analysis of MCT-treated rats shows significant collagen accumulation in the RV indicating the development of fibrosis. C, RVH determined as the ratio of RV to LV and intraventricular septum (S) weight [RV/(LV+S)]. Minocycline treatment exerts anti-fibrotic and anti-hypertrophic effects in the RV of MCT-treated rats. ‡p<0.001 vs. control and minocycline; ***p<0.001, *p<0.05 vs. MCT; †††p<0.001 vs. control and minocycline (n= 5–6 rats/group) (scale bar =20 μm). Data are represented as mean ± SEM, analyzed using one-way ANOVA with Newman-Keuls post hoc test. 2-way ANOVA showed significant interaction between MCT and minocycline on RVF (p=0.0016).