Skip to main content
. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Hypertension. 2018 Apr 30;71(6):1156–1163. doi: 10.1161/HYPERTENSIONAHA.118.10934

Figure 3. Anti-remodeling effects of minocycline in MCT-treated rats.

Figure 3

A, Representative micrographs show remodeling in pulmonary arteries of external diameter 25 to 50 μM stained with α-smooth muscle actin antibody and quantified for medial wall thickness (scale bar=100μm). B, Cumulative data of α-smooth muscle actin staining showing MCT caused significant increases in pulmonary medial wall thickness and this increase was significantly prevented by minocycline treatment. ‡p<0.001 vs. control and minocycline; ***p<0.001 vs. MCT (n= 6–7 rats/group). Data are represented as mean ± SEM, analyzed using one-way ANOVA with Newman-Keuls post hoc test. 2-way ANOVA showed significant interaction between MCT and minocycline on % medial wall thickness (p=0.0001).