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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Pflugers Arch. 2017 Dec 8;470(5):839–849. doi: 10.1007/s00424-017-2089-5

Figure 3.

Figure 3

Model of thermosensory transduction and adaptation pathways in AFD. Warming activates the AFD-rGCs GCY-8, GCY-18 and GCY-23 to increase intracellular cGMP concentrations. cGMP gates TAX-2/TAX-4-encoded cation channels. cGMP hydrolysis is mediated by PDEs such as PDE-2 whose activity may also be temperature-regulated. cGMP and/or Ca2+ feeds back to terminate signaling and promote rapid adaptation via inhibition of rGCs, activation of PDEs, and/or decreasing the sensitivity of the TAX-2/TAX-4 channels. Long-term adaptation of T*AFD also requires CMK-1-mediated changes in AFD-rGC and other gene expression. VGCCs - voltage-gated calcium channels (hypothesized). Adapted with permission from [95].