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Mean arterial pressure (MAP) and heart rate (HR) response to leptin infusion (2 μg/kg/min, iv) for 7 days). (A) Delta MAP and (B) HR in response to leptin in male and female SOCS3flox/flox and SOCS3-Nestin-Cre mice. *p<0.05 compared to SOCS3flox/flox mice.