Cardiometabolic responses to HFFD in male and female in SOCS3flox/flox (n=6–10) and SOCS3-Nestin-Cre (n=5–10) mice. Blood pressure and heart rate (HR) in SOCS3flox/flox and SOCS3flox/flox/Nestin-Cre mice were measured for 12/12 hrs day/night for 5 consecutive days. (A) Mean arterial pressure (MAP), (B) HR, (C) oxygen consumption (VO2), (D) blood glucose, (E) plasma insulin, and (F) plasma leptin concentrations. *p<0.05 compared to SOCS3flox/flox mice.