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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Pflugers Arch. 2018 Feb 27;470(5):745–759. doi: 10.1007/s00424-018-2120-5

Figure 3. Temperature range of mammalian thermo-TRPs.

Figure 3

Depicts the temperature-sensitive range of each thermo-TRP. TRPA1 (<17°C), TRPM8 (10°C – 26°C), TRPM2 (23°C – 28°C), TRPC5 (26°C – 38°C), TRPV4 (27°C – 34°C), TRPV3 (33 °C – 40°C), TRPM3 (>40°C), TRPV1 (>42°C), TRPV2 (>52°C). These overlap with psychophysical temperature ranges of noxious cold (<15°C), innocuous cold (10°C – 25°C), innocuous warmth (25°C – 42°C), noxious heat (42°C – 52°C), and extreme noxious heat (>52°C).