Table 1.

Summary of p53, p21 and Rb status of CDKi and Ki-67 sensitive cells

Cell line	Rb status (Sobecki et al. 2017)	p53 status (Leroy et al. 2014)	p21 induction upon Ki-67 KD (Sun et al., 2017)	CDKi sensitivity (Sobecki et al. 2017)	Ki-67 sensitivity (Sun et al., 2017)
IMR-90	+	+	+	+	+
MCF-7	+	+	+	+	+
HDF	+	+	+	+	+
hTERT-RPE1	+	+	+	ND	+
MDA-MB-231	+	R280K mutant, dominantly defective for transcriptional activation	−	+	−
MDA-MB-436	−	−	ND	−	ND
HCT116	+	+	−	−	−
HeLa	Inactivated by HPV	Inactivated by HPV	−	−	−
U2OS	−	+	−	−	−

HDF, Human diploid fibroblast; ND, not determined