Table 2.
Baseline characteristics of liver transplant waitlist registrants with liver disease other than hepatitis C, by cohort.
| Cohort 1 (2004) n=3,592 |
Cohort 2 (2009) n=4,164 |
Cohort 3 (2014) n=5,992 |
p-value | |
|---|---|---|---|---|
| Age, years, median (IQR) | 55 (48–61) | 57 (50–63) | 58 (50–64) | <0.001 |
| Men, n (%) | 1,988 (55.3) | 2,360 (56.7) | 3,633 (60.6) | <0.001 |
| Race/Ethnicity, n (%) | 0.10 | |||
| White | 2,701 (75.2) | 3,076 (73.9) | 4,397 (73.4) | |
| Black | 218 (6.1) | 232 (5.6) | 351 (5.9) | |
| Hispanic | 484 (13.5) | 616 (14.8) | 900 (15.0) | |
| Asian | 161 (4.5) | 200 (4.8) | 265 (4.4) | |
| Other | 28 (0.8) | 40 (1.0) | 79 (1.3) | |
| BMI(kg/m2), median (IQR) | 27.4 (24.0–31.9) | 27.5 (24.0–31.9) | 28.2 (24.4–32.4) | 0.047 |
| Diabetes mellitus, n (%) | 841 (24.3) | 1,157 (28.6) | 1,686 (28.3) | <0.001 |
| Hepatocellular carcinoma, n (%) | 350 (9.7) | 538 (12.9) | 755 (12.6) | <0.001 |
| Etiology, n (%) | <0.001 | |||
| Alcoholic liver disease | 976 (27.2) | 1,147 (27.5) | 1,889 (31.5) | |
| Nonalcoholic steatohepatitis | 11 (0.3) | 413 (9.9) | 1,039 (17.3) | |
| Cryptogenic cirrhosis | 714 (19.9) | 632 (15.2) | 578 (9.6) | |
| Primary sclerosing cholangitis | 317 (8.8) | 337 (8.1) | 479 (8.0) | |
| Primary biliary cirrhosis | 375 (10.4) | 278 (6.7) | 268 (4.5) | |
| Secondary biliary cirrhosis | 21 (0.6) | 12 (0.3) | 33 (0.6) | |
| Autoimmune hepatitis | 230 (6.4) | 284 (6.8) | 387 (6.5) | |
| Hepatitis B virus | 230 (6.4) | 170 (4.1) | 247 (4.1) | |
| Other | 718 (20.0) | 891 (21.4) | 1,072 (17.9) | |
| MELD score, median (IQR) | 13.0 (10.0–16.0) | 13.0 (10.0–16.0) | 14.0 (10.0–17.0) | <0.01 |
| Serum creatinine, median (IQR) | 0.9 (0.8–1.2) | 0.9 (0.7–1.2) | 0.9 (0.7–1.2) | 0.90 |
| Serum bilirubin, median (IQR) | 2.0 (1.3–3.2) | 1.9 (1.2–3.1) | 2.0 (1.2–3.3) | 0.02 |
| INR, median (IQR) | 1.3 (1.1–1.5) | 1.3 (1.1–1.4) | 1.3 (1.2–1.5) | <0.001 |
| Serum albumin, median (IQR) | 3.2 (2.7–3.6) | 3.2 (2.8–3.7) | 3.3 (2.8–3.7) | <0.001 |
| Serum sodium, median (IQR) | 138 (135–140) | 138 (136–140) | 138 (135–140) | 0.71 |
Abbreviations: IQR, interquartile range; BMI, body mass index; MELD, Model for End-stage Liver Disease; INR, international normalized ratio