Table 5.
Change in MELD(Delta-MELD) per year by cohort in liver transplant waitlist registrants with hepatitis C (HCV) or liver disease other than HCV.
| HCV | Non-HCV | |||
|---|---|---|---|---|
| Mean (SD) | Median (IQR) | Mean (SD) | Median (IQR) | |
| Total population | N=3,875 | N=6,584 | ||
| Cohort 1 | 2.07 (4.5) | 0.90 (−0.32–2.81) | 2.26 (4.9)a | 1.00 (−0.29–2.89) |
| Cohort 2 | 2.35 (4.9) | 0.91 (0.00–2.79) | 1.90 (4.4) | 0.84 (−0.38–2.58) |
| Cohort 3 | 1.90 (5.0)b | 0.68 (−0.43–2.36) | 1.66 (4.7)b | 0.61 (−0.60–2.41) |
|
| ||||
| Population excluding HCC | N=3,286 | N=6,000 | ||
| Cohort 1 | 2.16 (4.6) | 0.93 (−0.31–2.98) | 2.36 (5.0)b | 1.04 (0.00–2.98) |
| Cohort 2 | 2.45 (5.0) | 0.92 (0.00–2.84) | 1.89 (4.3) | 0.87 (−0.37–2.57) |
| Cohort 3 | 1.88 (5.0)b | 0.64 (−0.45–2.32) | 1.61 (4.7)b | 0.59 (−0.64–2.37) |
|
| ||||
| Baseline MELD above 20 | N=313 | N=577 | ||
| Cohort 1 | 4.39 (5.9) | 2.49 (0.56–6.26) | 3.68 (6.3) | 2.01 (0.31–4.99) |
| Cohort 2 | 3.70 (4.9) | 1.49 (0.33–7.21) | 3.38 (5.6) | 1.74 (−0.26–5.24) |
| Cohort 3 | 2.19 (5.9)b | 0.39 (−0.38–2.71) | 3.50 (5.6) | 1.64 (0.00–5.71) |
|
| ||||
| Baseline MELD below 20 | N=2,973 | N=5,423 | ||
| Cohort 1 | 2.00 (4.5) | 0.86 (−0.33–2.74) | 2.27 (4.9)b | 0.99 (0.00–2.89) |
| Cohort 2 | 2.36 (5.0) | 0.91 (0.00–2.73) | 1.76 (4.1) | 0.83 (−0.39–2.38) |
| Cohort 3 | 1.83 (4.9)b | 0.67 (−0.46–2.31) | 1.35 (4.5)b | 0.43 (−0.72–2.07) |
a
p-value <0.05 compared with Cohort 2
b
p-value <0.01 compared with Cohort 2
Abbreviations: SD, standard deviation; IQR, interquartile range; MELD, Model for End-stage Liver Disease; HCC, hepatocellular carcinoma