Table 2.
Differences of atopic history, signs and symptoms of atopic dermatitis between child and adult-onset of disease.
| Sign | Missing values | Age of AD onset$ | ||
|---|---|---|---|---|
| Childhood (<18) (n=207) | Adulthood (≥18) (n=149) | |||
| Freq (%) | Freq (%) | P-value# | ||
| Personal history | ||||
| Asthma | 8 | 104 (51.7%) | 26 (17.8%) | <0.0001 |
| Hay fever | 9 | 118 (58.7%) | 55 (37.7%) | 0.0001 |
| Food allergy | 14 | 87 (43.9%) | 22 (15.4%) | <0.0001 |
| Medication allergy | 18 | 64 (32.5%) | 43 (30.5%) | 0.70 |
| Family history | ||||
| Atopic dermatitis | 17 | 120 (60.6%) | 50 (35.5%) | <0.0001 |
| Asthma | 20 | 86 (43.9%) | 28 (20.0%) | <0.0001 |
| Hay fever | 21 | 71 (36.2%) | 33 (23.9%) | 0.017 |
| Food allergy | 33 | 47 (25.0%) | 14 (10.4%) | 0.0009 |
| Medication allergy | 33 | 28 (14.8%) | 12 (9.0%) | 0.12 |
| Physical signs | ||||
| Flexural dermatitis | 22 | 149 (76.4%) | 92 (66.2%) | 0.04 |
| Anterior neck fold dermatitis | 18 | 122 (61.0%) | 52 (37.7%) | <0.0001 |
| Facial dermatitis | 18 | 118 (59.0%) | 42 (30.4%) | <0.0001 |
| Conjunctivitis or eyelid dermatitis | 18 | 111 (55.5%) | 36 (26.1%) | <0.0001 |
| Dennie-Morgan fold | 18 | 75 (37.5%) | 16 (11.6%) | <0.0001 |
| Cheilitis | 18 | 79 (39.5%) | 17 (12.3%) | <0.0001 |
| Hand or foot dermatitis | 22 | 134 (68.7%) | 63 (45.3%) | <0.0001 |
| Nipple dermatitis | 22 | 29 (14.9%) | 7 (5.0%) | 0.004 |
| Xerosis | 16 | 162 (81.0%) | 113 (80.7%) | 0.95 |
| Pityriasis alba | 26 | 23 (12.0%) | 3 (2.2%) | 0.0007* |
| Palmar hyperlinearity/ichthyosis/keratosis pilaris | 22 | 121 (62.1%) | 45 (32.4%) | <0.0001 |
| Scalp | 18 | 96 (48.0%) | 35 (25.4%) | <0.0001 |
| Posterior auricular | 18 | 83 (41.5%) | 23 (16.7%) | <0.0001 |
| Nummular lesions | 29 | 12 (6.4%) | 21 (15.0%) | 0.0097 |
| White dermatographism | 24 | 8 (4.1%) | 6 (4.3%) | 0.94 |
| Follicular eczema | 21 | 11 (5.6%) | 7 (5.0%) | 0.82 |
| Anterior subcapsular cataracts | 17 | 6 (3.0%) | 8 (5.8%) | 0.21 |
| Keratoconus | 17 | 3 (1.5%) | 1 (0.7%) | 0.65* |
| Symptoms | ||||
| Clinical course worsened by environmental or emotional factors | 17 | 182 (91.9%) | 116 (82.3%) | 0.008 |
| Pruritus when sweating | 20 | 138 (70.1%) | 90 (64.7%) | 0.31 |
| Tendency toward cutaneous infections | 0 | 64 (30.9%) | 28 (18.85) | 0.0099 |
#
Chi-square test was used for all tests unless where indicated.
*
Fisher exact test
$
Column percentages are presented. Some frequencies may not sum to the total number of childhood and adult-onset cases due to missing values.