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. 2018 Apr 17;9(29):20409–20425. doi: 10.18632/oncotarget.24912

Table 4. Genes with CNAs showing significant association with tumors arising in specific colon sites by χ2 test.

GENE SYMBOL p-value Anatomic Site
Ascending
colon
(n = 7)
Cecum
(n = 6)
Descending
colon
(n = 7)
Hepatic Flexure
(n = 8)
Splenic Flexure (n = 5) Transverse
colon (n = 4)
Genes
with CN LOSS
MBD1 0.0005 Obs* = 0
Exp**= 0.75 (10.7%)
Obs = 0
Exp = 0.64 (10.7%)
Obs = 6 (85.7%)
Exp = 0.75 (10.7%)
Obs = 1 (12.5%)
Exp = 0.86 (10.7%)
Obs = 3 (60%)
Exp = 0.54 (10.7%)
Obs = 0
Exp = 0.43 (10.7%)
PDGFB 0.0008 Obs = 0
Exp = 0.56 (8%)
Obs = 0
Exp = 0.48 (8%)
Obs = 0
Exp = 0.56 (8%)
Obs = 0
Exp = 0.64 (8%)
Obs = 3 (60%)
Exp = 0.4 (8%)
Obs = 0
Exp = 0.32 (8%)
DCC 0.002 Obs = 1 (14.28%)
Exp = 2.45 (35%)
Obs = 1 (16.66%)
Exp = 2.1 (35%)
Obs = 6 (85.71%)
Exp = 2.45 (35%)
Obs = 1 (12.5%)
Exp = 2.81 (35%)
Obs = 4 (80%)
Exp = 1.75 (35%)
Obs = 0
Exp = 1.4 (35%)
WRN 0.007 Obs = 0
Exp = 0.94 (13%)
Obs = 0
Exp = 0.81 (13%)
Obs = 4 (57.14%)
Exp = 0.94 (13%)
Obs = 0
Exp = 1.08 (13%)
Obs = 0
Exp = 0.67 (13%)
Obs = 1 (25%)
Exp = 0.54 (13%)
NOTCH2 0.007 Obs = 0
Exp = 0.75 (11%)
Obs = 1 (16.66%)
Exp = 0.64 (11%)
Obs = 0
Exp = 0.75 (11%)
Obs = 0
Exp = 0.86 (11%)
Obs = 3 (60%)
Exp = 0.64 (11%)
Obs = 0
Exp = 0.43 (11%)
SMAD4 0.01 Obs = 0
Exp = 0.56 (8%)
Obs = 0
Exp = 0.48 (8%)
Obs = 3 (42.85%)
Exp = 0.56 (8%)
Obs = 0
Exp = 0.64 (8%)
Obs = 0
Exp = 0.4 (8%)
Obs = 0
Exp = 0.32 (8%)
RNF213 0.03 Obs = 1 (14.28%)
Exp = 1.7 (24%)
Obs = 0
Exp = 1.45 (24%)
Obs = 5 (71.42)
Exp = 1.7 (24%)
Obs = 2 (25%)
Exp = 1.94 (24%)
Obs = 0
Exp = 1.21 (24%)
Obs = 1 (25%)
Exp = 0.97 (24%)
APC 0.03 Obs = 0
Exp = 0.94 (13 %)
Obs = 0
Exp = 0.81 (13 %)
Obs = 3 (42.85%)
Exp = 0.94 (13 %)
Obs = 0
Exp = 1.08 (13 %)
Obs = 2 (40%)
Exp = 0.67 (13 %)
Obs = 0
Exp = 0.54 (13 %)
PIK3R1 0.03 Obs = 0
Exp = 0.94 (13%)
Obs = 0
Exp = 0.81 (13 %)
Obs = 3 (42.85%)
Exp = 0.94 (13 %)
Obs = 0
Exp = 1.08 (13 %)
Obs = 2 (40%)
Exp = 0.67 (13 %)
Obs = 0
Exp = 0.54 (13 %)
RET 0.04 Obs = 0
Exp = 1.13 (16%)
Obs = 0
Exp = 0.97 (16%)
Obs = 2 (28.57%)
Exp = 1.13 (16%)
Obs = 1 (12.5%)
Exp = 1.29 (16%)
Obs = 3 (60%)
Exp = 0.81 (16%)
Obs = 0
Exp = 0.64 (16%)
PKHD1 0.04 Obs = 0
Exp = 1.13 (16%)
Obs = 0
Exp = 0.97 (16%)
Obs = 2 (28.57%)
Exp = 1.13 (16%)
Obs = 1 (12.5%)
Exp = 1.29 (16%)
Obs = 3 (60%)
Exp = 0.81 (16%)
Obs = 0
Exp = 0.64 (16%)
Genes with CN GAIN RB1 0.01 Obs = 0
Exp = 0.56 (8%)
Obs = 0
Exp = 0.48 (8%)
Obs = 3 (42.85%)
Exp = 0.56 (8%)
Obs = 0
Exp = 0.64 (8%)
Obs = 0
Exp = 0.4 (8%)
Obs = 0
Exp = 0.32 (8%)
BCL2L1 0.01 Obs = 0
Exp = 0.37 (5%)
Obs = 0
Exp = 0.32 (5%)
Obs = 0
Exp = 0.37 (5%)
Obs = 0
Exp = 0.43 (5%)
Obs = 2 (40%)
Exp = 0.27 (5%)
Obs = 0
Exp = 0.21 (5%)
UBR5 0.02 Obs = 0
Exp = 2.45 (35%)
Obs = 0
Exp = 2.1 (5%)
Obs = 4 (57.14%)
Exp = 2.45 (5%)
Obs = 3 (37.5%)
Exp = 2.81 (5%)
Obs = 4 (80%)
Exp = 1.75 (5%)
Obs = 2 (50%)
Exp = 1.4 (5%)

*Obs: Observed CC patients showing CNAs.

**Exp: Expected CC patients showing CNAs.