Table 1. A summary of the K_D data calculated for GR01 and GR02.

Ligand	huGR	huAR	huPR	huER	huMR	msGR	rtGR
Ref.	2.03 × 10–9	4.96 × 10–10	6.27 × 10–10	6.94 × 10–9	1.41 × 10–8	ND	ND
GR01	3.86 × 10–9	1.46 × 10–6	1.06 × 10–6	9.78 × 10–7	2.12 × 10–7	ND	ND
GR02	1.59 × 10–8	1.26 × 10–6	2.42 × 10–7	2.07 × 10–5	4.03 × 10–6	6.71 × 10–9	6.18 × 10–9

Data were calculated with competition binding assays displacing ³H-steroid agonists for the respective human (hu), mouse (ms), and rat (rt) nuclear hormone receptor on cells. Data are reported as [M]. Reference compounds (Ref.) are positive control agonists or antagonists: dexamethasone (GR), dihydrotestosterone (AR), progesterone (PR), 4-OH-tamoxifen (ER), and eplerenone (MR). ND = not determined.