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. 2018 Apr 17;9(29):20323–20338. doi: 10.18632/oncotarget.24859

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Copyright: © 2018 Agarwal et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) The MYCN-ChIP-Seq database and p53-ChIP-Seq composite database were analyzed to determine binding patterns at the MYCN (E-box) and p53 (p53-RE) promoters in the top genes. The p53-repressed and p53-activated genes under low MYCN or high MYCN conditions were analyzed and summarized here for the presence or absence of E-box and p53-REs. Top 30 genes in each category by fold change were analyzed. Red= MYCN E-box present; Blue= p53-RE present. (B) Functional annotations of p53 response genes under high MYCN condition were analyzed and found to be highly correlated with worse prognosis and MYCN levels in NB patients. R2: Kosak (n=498) dataset of NB patient was used.