Table 2. List of all candidate miRNAs from the discovery phase stratified for BC invasiveness that were selected for replica/validation phase.

	Mean read counts	log2 Fold Change	adj P (FDR)	PP
Candidate miRNAs for MIBC
amiR-21-5p	29223	1.42	0.01	0.85
amiR-106b-3p	130	2.53	0.00	0.85
bmiR-30a-5p	19453	–1.80	0.05	0.85
blet-7c-5p	1497	–1.62	0.02	0.85
bmiR-486-5p	819	3.68	0.01	<0.70
cmiR-205-5p	376	2.97	0.00	0.9
miR-451a	1004	3.40	0.04	<0.70
miR-25-3p	588	1.99	0.02	<0.70
miR-7-1-5p	518	3.32	0.05	0.85
miR-146a-5p	420	2.49	0.04	<0.70

Candidate miRNAs for NMIBC G1 + G2
dmiR-30c-2-5p	2106	–0.73	0.00	<0.70
dmiR-151a-3p	2873	0.34	0.02	<0.70
bmiR-30a-5p	27229	–0.63	0.00	0.73
blet-7c-5p	2644	–0.43	0.04	0.71
bmiR-486-5p	1868	1.94	0.02	<0.70
cmiR-205-5p	479	1.82	0.00	0.73
let-7i-5p	5038	0.55	0.03	<0.70

Candidate miRNAs for NMIBC G3
amiR-21-5p	38624	0.87	0.03	0.76
amiR-106b-3p	184	2.30	0.00	0.88
bmiR-30a-5p	29232	–1.67	0.00	0.76
blet-7c-5p	2939	–1.17	0.03	<0.70
bmiR-486-5p	2918	3.14	0.00	<0.70
dmiR-30c-2-5p	2241	–1.47	0.01	<0.70
dmiR-151a-3p	3884	0.51	0.03	<0.70
miR-10b-5p	28018	–1.88	0.00	0.85
miR-148b-3p	660	0.95	0.00	0.85
miR-183-5p	1414	1.50	0.00	<0.70
miR-185-5p	381	2.10	0.00	0.76
miR-200c-3p	9145	1.11	0.00	0.76
miR-224-5p	488	2.97	0.00	0.79
miR-4448	7834	–2.27	0.01	<0.70
miR-98-5p	459	1.01	0.01	0.79

Abbreviations: FDR false discovery rate, PP predictive power, MIBC muscle-invasive bladder cancer, NMIBC non-muscle invasive bladder cancer.

^amiRNAs in common between NMIBC G3 and MIBC.

^bmiRNAs in common among NMIBC G1 + G2, NMIBC G3, and MIBC.

^cmiRNAs in common between NMIBC G1 + G2 and MIBC.

^dmiRNAs in common between NMIBC G1 + G2 and NMIBC G3.