Table 3. Response of aGVHD to MSC therapy: definitions.

Types of response	Overall grade response*
Complete response (CR)	Resolution of all signs of aGVHD (aGVHD overall grade = 0)*
Partial response (PR)	Decrease of the aGVHD overall grade by at least 1 grade as compared with baseline overall grade*
Overall response (OR)	Achievement of either CR or PR
No response (No R)	Not fulfilling criteria for CR or PR
Response at day 30 after first MSC infusion
CRd30	Achievement of CR at day 30 after first MSC infusion
PRd30	Achievement of PR at day 30 after first MSC infusion
ORd30	Achievement of either CRd30 or PRd30
No Rd30	Not fulfilling criteria for CRd30 or PRd30
Best response observed within the 90-day period after first MSC infusion
CR<90d	Achievement of CR as best response at least at one time-point within 90 days after first MSC infusion
PR<90d	Achievement of PR as best response at least at one time-point within 90 days after first MSC infusion
OR<90d	Achievement of either CR<90d or PR<90d
No R<90d	Not fulfilling criteria for CR<90d or PR<90d
1-month maintenance of CR within the 90-day period after first MSC infusion
Sustained complete response (CR ≥ 1m)	CR maintained for at least 1 consecutive month

^*Organ (skin, gut, liver) specific responses were also assessed according to the initially affected organs at baseline. CR was defined as resolution of all signs of aGVHD in the specific organ (aGVHD stage in the specific organ = 0). PR was defined as decrease of the aGVHD stage in the specific organ by at least 1 stage as compared with baseline stage.