Table 1.
Genes with statistically significant splicing identified by all three bioinformatics methods (FIRMA, MIDAS, ANOSVA)
| Splicing of a single exon | Splicing of 2–4 consecutive exons | Splicing of >5 consecutive exons | ||
|---|---|---|---|---|
| RPL11 | ILF2 | SPARC | CCNA2 | IARS2 |
| NEXN | ZBTB41 | SOX4 | SLC17A5 | BUB1 |
| CEP350 | USP34 | STXBP5 | EZH2 | ALCAM |
| PRDX1 | IDH1 | BRAF | RDH10 | APP |
| PDIA6 | VCAN | PRKDC | PTK2 | TNFRSF21 |
| SEC61A1 | SSR1 | SIRT1 | CAPRIN1 | LEMD3 |
| LAT2 | SMC2 | MARS | ESYT1 | CAND1 |
| SPIN1 | TAOK1 | ATP2A2 | GDE1 | TRIM33 |
| TTC17 | MED13 | SLC38A1 | GNAS | MANF |
| PCGF2 | GATA6 | DLGAP5 | RABGAP1L | THBS2 |
| GNA13 | DSG2 | RPN2 | COL12A1 | ADAMTS9 |
| GALNT1 | SLC39A6 | PSMA7 | MTCH2 | TPX2 |
| TCF3 | GNB1 | CCT2 | COL5A2 | |
| YTHDF1 | MATR3 | CLSPN | ||
| HMGXB4 | CCNJ | |||
| RCC2 | ZBTB44 | |||
| DARS | RAP2A | |||
| TFRC | YY1 | |||
| KIF23 | ||||
Genes were separated in three categories based on the number of consective exons spliced
The list of 76 genes identified was divided into 3 categories, based on FIRMA significance analysis: genes with splicing in 1 exon, genes with splicing in 2–4 adjacent exons, and genes with splicing in 5 adjacent exons
MIDAS microarray detection of alternative splicing, FIRMA finding isoforms using robust multichip analysis, ANOSVA analysis of splice variation